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Some more information on Ribozymes

 
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kellylen
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Joined: 21 Nov 2006
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PostPosted: Wed May 30, 2007 8:16 am    Post subject: Some more information on Ribozymes Reply with quote

Here Dan. I posted this up in the comments about the video but I don't want you to miss it.

From my text book

Quote:
The idea of a catalytic role for snRNA arose from the discovery of ribozymes. RNA molecules that function as enzymes. In some organisms, RNA splicing can occur without proteins or additional RNA molecules: The intron RNA functions as a ribozyme and catalyzes its own excision! For example, in the protozoan Tetrahymena, self-splicing occues in the production of ribosomal RNA (rRNA), a component of the organism's ribosomes. The pre-rRna actually removes it's own introns.
The fact that RNA is single stranded plays an important role in allowing certain RNA molecules to function as ribozymes. A region of an RNA molecules may base-pair with a complementary region elsewhere in the same molecules, this imparting specific structure to the RNA molecules as a whole. Also, some of the bases contain functional groups that may participate in catalysis. Just as the specific shape of an enzymatic protein and the functional groups on its amino acid side chains allow the protein to function as a catalyst, the structure of some RNA molecules allows them to function as catalysts too. The discovery of ribozymes rendered obsolete the belief that all biological catalysts were proteins.



RNA processing: RNA splicing. The RNA molecule shown here codes for beta-globin, one of the polypeptides of hemoglobin. the numbers under the RNA reger to codons; beta-globin is 146 amino acids long. the beta-globin gene and its pre-mRNA transcript have three exons, corrresponding to sequences that will leave the nucleus as mRNA. the 5' UTR and 3' UTE are partes of exons because they are included in the mRNAl however, they do not code for protein.) During RNA processing, the introns are cut out and the exons spliced together.

Quote:
Thomas Cech, of the University of Colorade and Sidney Altman of Yale University found that RYNA, which plays a central role in protein synthesis, can also carry out a number of enzyme-like catalytic functions. Cech called these RNA catalysts Ribozymes. Some ribosymes can make complementary copies of short pieces of RNA, provided that they are supplied with nucleotide building blocks.



a ribozyme capable of replicating RNA. This RNA molecule can make a complementary copy of another piece of RNA (a template_ containing up to 14 nucleotides.

I'm going to go look in another text book of mine and get back to you Smile
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BrightSilence
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Joined: 23 May 2007
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PostPosted: Wed May 30, 2007 9:55 am    Post subject: Reply with quote

This topic makes me feel very dumb. When you find something definate, you will explain in plain english right?

*Shouts out to every RNA specialist, to come over here and help!*
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Haether
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Joined: 27 Apr 2007
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PostPosted: Wed May 30, 2007 11:03 am    Post subject: Reply with quote

basically, ribozymes cut up RNA. This is a part of normal body processes (like making proteins), but this capability can also be used to stop "bad genes" from being expressed, like cancer genes (I'm sure you've heard about the gene for breast cancer--ribozymes can work on that to stop it from being expressed and allowing tumors to grow)
They're also being studied for antiviral applications and eventually, by treating all these diseases, we have the potential to live forever.

one interesting point is that ribozymes can be made in the lab to the specifications that researchers need, so we really have to wonder if that is the real reason they're taking Bree. I mean, if she has special ribozymes that act on a certain sequence of RNA, all they would have to do is take a tissue sample from her.

I think we need more information. It would be nice if Daniel would post everything they have!! I mean, sending stuff to Taylor is all well and good, but she's a high school student. It makes sense to post it on the board where people from much more diverse backgrounds (and more training) can look at it.
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BrightSilence
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PostPosted: Wed May 30, 2007 11:11 am    Post subject: Reply with quote

Haether wrote:
It makes sense to post it on the board where people from much more diverse backgrounds (and more training) can look at it.

It would, unless you want to keep the info private. They might have a reason not to share it with us (yet... I hope)
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