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Spencer the solution!
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kellylen
The Order of Denderah


Joined: 21 Nov 2006
Posts: 2823
Location: New Jersey

PostPosted: Wed Jul 11, 2007 9:17 pm    Post subject: Spencer the solution! Reply with quote

Hey hun Smile

Here is the tentative solution to the papers you gave us today

Quote:
The Bree Solution (that sounds REALLY important Shocked)
Objectives:
How to tansform Bree from TRAIT: POSITIVE to TRAIT:NEGATIVE

Given Facts:
1) Bree's blood contains a special Ribozyme mutated and unique only to her
2) The Gene for said ribozyme has a regulatory hyper mutation that changes with every generation
3) A non-functioning mutated ribozyme exists and manifests differently in every Hymn of One girl
4) This portion still functions but you cannot block it because the Complementary Strand of RNA won't copy

Theoretical Solution
1) Block the ribozyme in question by obtaining a sample of the that same ribozyme in order to copy it
2) Create a complementary strand of RNA
3) Q.E.D. strand will bind to ribozyme and occlude its copy

Practical Solution
1) obtain blood sample of Bree
2) synthesize complimentary strand of RNA
3) inject bree with this compliementary strand
4) Q.E.D. ribozymes blocked rendered ineffectual

Intended Results
1) Once synthesized and injected into bree she'll become trait negative
2) additional consequences (if any) - TBD

Bree Trait Reference Points
Theories concerning ribozyme function
a)RNAse P related -tRNA cleavage
b)splicosome related - intron/exon splicing
c)Hammerhead related - telomere synthesis
d)GlmS ribozyme related - fructose 6-phosphate pathway


this is what we think so far. and most of it is 99% sure on Smile
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Last edited by kellylen on Wed Jul 11, 2007 9:52 pm; edited 2 times in total
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Samara
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Joined: 30 Nov 2006
Posts: 356

PostPosted: Wed Jul 11, 2007 9:46 pm    Post subject: Reply with quote

To be honst, I think this solution was posted in haste. For example:

Quote:
defunctual


That's not actually a word...

I believe that the word is "ineffectual"
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kellylen
The Order of Denderah


Joined: 21 Nov 2006
Posts: 2823
Location: New Jersey

PostPosted: Wed Jul 11, 2007 9:49 pm    Post subject: Reply with quote

fixed it. the point is that the foundation is there. the important parts are there. a word here or there will not... or well should not throw off the whole thing
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anniid
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Joined: 08 Dec 2006
Posts: 241
Location: A snowflake

PostPosted: Wed Jul 11, 2007 9:49 pm    Post subject: Look at us. we're so cool... Reply with quote

See!?
You should have posted that paper sooner... within 2-3 hours we had a solution. (It's correctness is um... relative...)
Alright. Check our solution and give us another puzzle!!!
Come on... you know you want to, Spencer.
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ohpete
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Joined: 11 Jul 2007
Posts: 40

PostPosted: Wed Jul 11, 2007 10:13 pm    Post subject: Reply with quote

theres my copy. im too exauhsted to check it against yours for the moment kelly. ive got to get some food in me. but here it is as a back up.

The Bree Solution (that sounds REALLY important )
Objectives:
How to transform Bree from TRAIT: POSITIVE to TRAIT: NEGATIVE

Given Facts:
1) Bree's blood contains a special ribozyme mutated and unique only to her.
2) The gene for said ribozyme has a regulatory hyper mutation that changes with every generation.
3) A non-functioning mutated (?) ribozyme exists and manifests differently in every Hymn of One girl.
4) This portion still functions but you cannot block it because the complimentary strands of RNA won't copy.

Theoretical Solution
1) Block the ribozyme in question by obtaining a sample of that same ribozyme in order to copy it.
2) Create complimentary strand of RNA.
3) Q.E.D. strand will bind to ribozyme and occlude its copy.

Practical Solution
1) Obtain blood sample of Bree.
2) Synthesize complimentary strand of RNA
3) Inject Bree with this complementary strand.
4) Q.E.D. ribozymes blocked will be rendered ineffectual.

Intended Results
1) Once synthesized and injected into Bree she'll become trait negative
2) Additional consequences (if any) - TBD

Bree Trait Reference Points
The steps concerning ribozyme function
RNAse P related -tRNA cleavage
Splicosome related - intron/exon splicing
Hammerhead or Telomerase(?) related - telomere synthesis
GlmS ribozyme related - fructose 6-phosphate pathway
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SivartAlappes
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Joined: 02 Oct 2006
Posts: 209
Location: Virginia but moving to Cali soon

PostPosted: Wed Jul 11, 2007 10:14 pm    Post subject: Re: Look at us. we're so cool... Reply with quote

anniid wrote:
See!?
You should have posted that paper sooner... within 2-3 hours we had a solution. (It's correctness is um... relative...)
Alright. Check our solution and give us another puzzle!!!
Come on... you know you want to, Spencer.


1 hour and 41 minutes, actually.
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kellylen
The Order of Denderah


Joined: 21 Nov 2006
Posts: 2823
Location: New Jersey

PostPosted: Wed Jul 11, 2007 10:15 pm    Post subject: Re: Look at us. we're so cool... Reply with quote

SivartAlappes wrote:
anniid wrote:
See!?
You should have posted that paper sooner... within 2-3 hours we had a solution. (It's correctness is um... relative...)
Alright. Check our solution and give us another puzzle!!!
Come on... you know you want to, Spencer.


1 hour and 41 minutes, actually.


actually i think its a lot less than that
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emerrs11
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Joined: 29 Dec 2006
Posts: 168
Location: In the cactus HQ

PostPosted: Wed Jul 11, 2007 10:17 pm    Post subject: Reply with quote

I agree Kelly! I am 99.99% sure. I trust these answers as much as I trust Neutragena!
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SivartAlappes
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Joined: 02 Oct 2006
Posts: 209
Location: Virginia but moving to Cali soon

PostPosted: Wed Jul 11, 2007 10:20 pm    Post subject: Re: Look at us. we're so cool... Reply with quote

kellylen wrote:
SivartAlappes wrote:
anniid wrote:
See!?
You should have posted that paper sooner... within 2-3 hours we had a solution. (It's correctness is um... relative...)
Alright. Check our solution and give us another puzzle!!!
Come on... you know you want to, Spencer.


1 hour and 41 minutes, actually.


actually i think its a lot less than that



Well, the 1 hour and 41 minutes is the time between when Spencer posted the letter, and when you posted the solution.
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Aponi
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Joined: 26 Apr 2007
Posts: 545
Location: New York

PostPosted: Wed Jul 11, 2007 10:21 pm    Post subject: Re: Look at us. we're so cool... Reply with quote

kellylen wrote:
SivartAlappes wrote:
anniid wrote:
See!?
You should have posted that paper sooner... within 2-3 hours we had a solution. (It's correctness is um... relative...)
Alright. Check our solution and give us another puzzle!!!
Come on... you know you want to, Spencer.


1 hour and 41 minutes, actually.


actually i think its a lot less than that


It was posted around 9:30, and by the time I was done with it enough to look at the clock it was around 11. Sounds about right to me Smile

And I have to say, WTG US! Puzzle-solving ftw Smile
Seriously, props to everyone who helped (Yes Kelly, even Travis XD)
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QtheC
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Joined: 22 Feb 2007
Posts: 374

PostPosted: Wed Jul 11, 2007 10:35 pm    Post subject: Reply with quote

Quote:
3) Q.E.D. strand will bind to ribozyme and occlude its copy


Quote:
4) Q.E.D. ribozymes blocked rendered ineffectual


I can neither confirm nor deny ever having E.D.'d, but I'm willing to try it if it will help the cause, and someone can provide me with step by step instructions and the necessary ribozymes. As long as it is no harder than Sea-Monkeys, I should have or be able to improvise any laboratory equipment needed (tupperware, microwave, blender, power tools, hybrid bicycle, fire, nails, ziplock bags, Dr. Pepper, batteries). Let me know if I have left anything important off the list - I might have it.
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anniid
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Joined: 08 Dec 2006
Posts: 241
Location: A snowflake

PostPosted: Wed Jul 11, 2007 10:52 pm    Post subject: Re: Look at us. we're so cool... Reply with quote

kellylen wrote:
SivartAlappes wrote:
anniid wrote:
See!?
You should have posted that paper sooner... within 2-3 hours we had a solution. (It's correctness is um... relative...)
Alright. Check our solution and give us another puzzle!!!
Come on... you know you want to, Spencer.


1 hour and 41 minutes, actually.


actually i think its a lot less than that

well his first post was at 7:30--something.
then we finished at 9:17
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Acting president of the Jonas is Sexy Fan Club!
Member of the Sarah Fan Club and the Daniel-Sarah Romance Promotion Force.
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thoughtssopoetic
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Joined: 24 Jun 2007
Posts: 429
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PostPosted: Wed Jul 11, 2007 11:19 pm    Post subject: Re: Look at us. we're so cool... Reply with quote

anniid wrote:
kellylen wrote:
SivartAlappes wrote:
anniid wrote:
See!?
You should have posted that paper sooner... within 2-3 hours we had a solution. (It's correctness is um... relative...)
Alright. Check our solution and give us another puzzle!!!
Come on... you know you want to, Spencer.


1 hour and 41 minutes, actually.


actually i think its a lot less than that

well his first post was at 7:30--something.
then we finished at 9:17


I am now cursing the fact that I have night class from 6-9:30
gah.
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BlackCatonMars
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Joined: 02 May 2007
Posts: 33
Location: Rochester, NY

PostPosted: Thu Jul 12, 2007 2:14 am    Post subject: Re: Look at us. we're so cool... Reply with quote

thoughtssopoetic wrote:


I am now cursing the fact that I have night class from 6-9:30
gah.


I was eating dinner and then watching the movie Sneakers and didn't get back online until I was of no use...and I've been waiting for weeks for a chance to help out! Oh well.
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marlasinger
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Joined: 27 Feb 2007
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Location: The 8th Dimension

PostPosted: Thu Jul 12, 2007 7:54 am    Post subject: Reply with quote

wooooooord! Kelly we posted that theory that i was talking about last night here http://www.lonelygirl15.com/forum/viewtopic.php?t=12203. Take a look and tell me what you think - things to remember - no double stranded rna (rNAi), just complementary and active strands. Someone's already mentioned that it might be science fiction.
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The Bree Solution.
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